ISSN 1662-4009 (online)

ey0017.9-11 | Premature Aging, Cardiometabolic Fitness and Cardiovascular Damage | ESPEYB17

9.11. Retinal vessel analysis as a novel screening tool to identify childhood acute lymphoblastic leukemia survivors at risk of cardiovascular disease

MS Azanan , S Chandrasekaran , ES Rosli , LL Chua , L Oh , TF Chin , TY Yap , R Rajagopal , R Rajasuriar , T MacGillivray , E Trucco , N Ramli , TA Kamalden , H Ariffin

To read the full abstract: J Pediatr Hematol Oncol. 2020;10.1097/MPH.0000000000001766. doi:10.1097/MPH.0000000000001766 [published online ahead of print, 2020 Feb 28]. taftkamalden@um.edu.myChildhood cancer survivors (CCS) have a markedly increased incidence of early cardiovascular disease (CVD). Changes in retinal vessel diameter are associa...

ey0015.9-4 | Late effects of tumour therapy: molecular evidences of premature cellular aging | ESPEYB15

9.4 Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging

H Ariffin , MS Azanan , SS Abd Ghafar , L Oh , KH Lau , T Thirunavakarasu , A Sedan , K Ibrahim , A Chan , TF Chin , FF Liew , S Jeyamogan , ES Rosli , R Baharudin , TY Yap , R Skinner , SH Lum , P Hainaut

To read the full abstract: Cancer. 2017;123:4207-4214Metabolic syndrome and early cardiovascular disease are well-known long-term complications of cancer treatment during childhood, but the underlying causes are still unclear. It had been already demonstrated that the abnormalities of the immune system, that are characteristic of the elderly population, may become evident earlier in childhood cancer...